The Hotel Nikko Osaka is an Osaka hotel located in the suburbs of Nishi-Shinsaibashi, around the heart of the CBD. The hotel faces the green and welcoming Mido-Suji Avenue. The Hotel Nikko Osaka is located at 1-3-3, Nishi-shinsaibashi in Osaka, Japan. Hommachi, the city's business center, is just a short walking distance from the hotel.

The Hotel Nikko Osaka features modern comforts in all 640 of its guestrooms. Its architectural style has been well reviewed and the 27th floor was actually designed by Japanese designer Hanae Mori. Room service is traditionally Japanese and among the most accommodating in the world.

Amenities at the Hotel Nikko Osaka include on-site restaurants that serve Chinese, French, and Japanese cuisine. There is also a piano bar that offers live piano music and some of the best liquors from all over the globe. Families and business travelers can make use of banqueting facilities. There are also rooms specifically set up for conferencing. This is a five-star hotel.